Factors Associated With Persistent Increase in Level of Alanine Aminotransferase in Patients With Chronic Hepatitis B Receiving Oral Antiviral Therapy.
Identifieur interne : 000C36 ( Main/Exploration ); précédent : 000C35; suivant : 000C37Factors Associated With Persistent Increase in Level of Alanine Aminotransferase in Patients With Chronic Hepatitis B Receiving Oral Antiviral Therapy.
Auteurs : Ira M. Jacobson [États-Unis] ; Mary K. Washington [États-Unis] ; Maria Buti [Espagne] ; Alexander Thompson [Australie] ; Nezam Afdhal [États-Unis] ; Robert Flisiak [Pologne] ; Ulus Salih Akarca [Turquie] ; Konstantin G. Tchernev [Bulgarie] ; John F. Flaherty [États-Unis] ; Raul Aguilar Schall [États-Unis] ; Robert P. Myers [États-Unis] ; G Mani Subramanian [États-Unis] ; John G. Mchutchison [États-Unis] ; Zobair Younossi [États-Unis] ; Patrick Marcellin [France] ; Keyur Patel [États-Unis]Source :
- Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association [ 1542-7714 ] ; 2017.
Abstract
Despite complete suppression of viral DNA with antiviral agents, in some patients with chronic hepatitis B (CHB), serum levels of alanine aminotransferase (ALT) do not normalize. We investigated factors associated with persistent increases in ALT level in patients with CHB given long-term tenofovir disoproxil fumarate.
DOI: 10.1016/j.cgh.2017.01.032
PubMed: 28215615
Affiliations:
- Australie, Bulgarie, Espagne, France, Pologne, Turquie, États-Unis
- Californie, Caroline du Nord, Catalogne, Massachusetts, Sofia-ville (oblast), Tennessee, Virginie, État de New York
- Barcelone, Sofia
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Jacobson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Mount Sinai Beth Israel Medical Center, New York, New York. Electronic address: ira.jacobson@nyumc.org.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Medicine, Mount Sinai Beth Israel Medical Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Washington, Mary K" sort="Washington, Mary K" uniqKey="Washington M" first="Mary K" last="Washington">Mary K. Washington</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Buti, Maria" sort="Buti, Maria" uniqKey="Buti M" first="Maria" last="Buti">Maria Buti</name><affiliation wicri:level="3"><nlm:affiliation>Servei de Medicina Interna-Hepatologia, Hospital General Universitari Vall d'Hebron, and Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (CIBERHED) del Instituto Carlos III, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servei de Medicina Interna-Hepatologia, Hospital General Universitari Vall d'Hebron, and Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (CIBERHED) del Instituto Carlos III, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Thompson, Alexander" sort="Thompson, Alexander" uniqKey="Thompson A" first="Alexander" last="Thompson">Alexander Thompson</name><affiliation wicri:level="1"><nlm:affiliation>Hepatology Research, St Vincent's Hospital, Fitzroy, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Hepatology Research, St Vincent's Hospital, Fitzroy, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Afdhal, Nezam" sort="Afdhal, Nezam" uniqKey="Afdhal N" first="Nezam" last="Afdhal">Nezam Afdhal</name><affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Flisiak, Robert" sort="Flisiak, Robert" uniqKey="Flisiak R" first="Robert" last="Flisiak">Robert Flisiak</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok</wicri:regionArea><wicri:noRegion>Bialystok</wicri:noRegion></affiliation></author><author><name sortKey="Akarca, Ulus Salih" sort="Akarca, Ulus Salih" uniqKey="Akarca U" first="Ulus Salih" last="Akarca">Ulus Salih Akarca</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, Ege Universitesi Tip Fakultesi, Izmir, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Gastroenterology, Ege Universitesi Tip Fakultesi, Izmir</wicri:regionArea><wicri:noRegion>Izmir</wicri:noRegion></affiliation></author><author><name sortKey="Tchernev, Konstantin G" sort="Tchernev, Konstantin G" uniqKey="Tchernev K" first="Konstantin G" last="Tchernev">Konstantin G. Tchernev</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Diseases, Medical University, Sofia, Bulgaria.</nlm:affiliation><country xml:lang="fr">Bulgarie</country><wicri:regionArea>Department of Internal Diseases, Medical University, Sofia</wicri:regionArea><placeName><settlement type="city">Sofia</settlement><region nuts="2">Sofia-ville (oblast)</region></placeName></affiliation></author><author><name sortKey="Flaherty, John F" sort="Flaherty, John F" uniqKey="Flaherty J" first="John F" last="Flaherty">John F. Flaherty</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City</wicri:cityArea></affiliation></author><author><name sortKey="Aguilar Schall, Raul" sort="Aguilar Schall, Raul" uniqKey="Aguilar Schall R" first="Raul" last="Aguilar Schall">Raul Aguilar Schall</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City</wicri:cityArea></affiliation></author><author><name sortKey="Myers, Robert P" sort="Myers, Robert P" uniqKey="Myers R" first="Robert P" last="Myers">Robert P. Myers</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City</wicri:cityArea></affiliation></author><author><name sortKey="Subramanian, G Mani" sort="Subramanian, G Mani" uniqKey="Subramanian G" first="G Mani" last="Subramanian">G Mani Subramanian</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City</wicri:cityArea></affiliation></author><author><name sortKey="Mchutchison, John G" sort="Mchutchison, John G" uniqKey="Mchutchison J" first="John G" last="Mchutchison">John G. Mchutchison</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Departments of Clinical Research and Clinical Biometrics, Gilead Sciences, Inc, Foster City</wicri:cityArea></affiliation></author><author><name sortKey="Younossi, Zobair" sort="Younossi, Zobair" uniqKey="Younossi Z" first="Zobair" last="Younossi">Zobair Younossi</name><affiliation wicri:level="2"><nlm:affiliation>Center for Liver Diseases, Department of Medicine, Inova Fairfax Hospital, Falls Church, Virginia.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Center for Liver Diseases, Department of Medicine, Inova Fairfax Hospital, Falls Church</wicri:cityArea></affiliation></author><author><name sortKey="Marcellin, Patrick" sort="Marcellin, Patrick" uniqKey="Marcellin P" first="Patrick" last="Marcellin">Patrick Marcellin</name><affiliation wicri:level="1"><nlm:affiliation>Service d'Hépatologie, Viral Hepatitis Research Centre, Hôpital Beaujon, Clichy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'Hépatologie, Viral Hepatitis Research Centre, Hôpital Beaujon, Clichy</wicri:regionArea><wicri:noRegion>Clichy</wicri:noRegion><wicri:noRegion>Clichy</wicri:noRegion></affiliation></author><author><name sortKey="Patel, Keyur" sort="Patel, Keyur" uniqKey="Patel K" first="Keyur" last="Patel">Keyur Patel</name><affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Division of Gastroenterology, Duke Clinical Research Institute, Duke University Medical Center, Durham</wicri:cityArea></affiliation></author></analytic><series><title level="j">Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association</title><idno type="eISSN">1542-7714</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Despite complete suppression of viral DNA with antiviral agents, in some patients with chronic hepatitis B (CHB), serum levels of alanine aminotransferase (ALT) do not normalize. We investigated factors associated with persistent increases in ALT level in patients with CHB given long-term tenofovir disoproxil fumarate.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Bulgarie</li><li>Espagne</li><li>France</li><li>Pologne</li><li>Turquie</li><li>États-Unis</li></country><region><li>Californie</li><li>Caroline du Nord</li><li>Catalogne</li><li>Massachusetts</li><li>Sofia-ville (oblast)</li><li>Tennessee</li><li>Virginie</li><li>État de New York</li></region><settlement><li>Barcelone</li><li>Sofia</li></settlement></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Jacobson, Ira M" sort="Jacobson, Ira M" uniqKey="Jacobson I" first="Ira M" last="Jacobson">Ira M. Jacobson</name></region><name sortKey="Afdhal, Nezam" sort="Afdhal, Nezam" uniqKey="Afdhal N" first="Nezam" last="Afdhal">Nezam Afdhal</name><name sortKey="Aguilar Schall, Raul" sort="Aguilar Schall, Raul" uniqKey="Aguilar Schall R" first="Raul" last="Aguilar Schall">Raul Aguilar Schall</name><name sortKey="Flaherty, John F" sort="Flaherty, John F" uniqKey="Flaherty J" first="John F" last="Flaherty">John F. Flaherty</name><name sortKey="Mchutchison, John G" sort="Mchutchison, John G" uniqKey="Mchutchison J" first="John G" last="Mchutchison">John G. Mchutchison</name><name sortKey="Myers, Robert P" sort="Myers, Robert P" uniqKey="Myers R" first="Robert P" last="Myers">Robert P. Myers</name><name sortKey="Patel, Keyur" sort="Patel, Keyur" uniqKey="Patel K" first="Keyur" last="Patel">Keyur Patel</name><name sortKey="Subramanian, G Mani" sort="Subramanian, G Mani" uniqKey="Subramanian G" first="G Mani" last="Subramanian">G Mani Subramanian</name><name sortKey="Washington, Mary K" sort="Washington, Mary K" uniqKey="Washington M" first="Mary K" last="Washington">Mary K. Washington</name><name sortKey="Younossi, Zobair" sort="Younossi, Zobair" uniqKey="Younossi Z" first="Zobair" last="Younossi">Zobair Younossi</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Buti, Maria" sort="Buti, Maria" uniqKey="Buti M" first="Maria" last="Buti">Maria Buti</name></region></country><country name="Australie"><noRegion><name sortKey="Thompson, Alexander" sort="Thompson, Alexander" uniqKey="Thompson A" first="Alexander" last="Thompson">Alexander Thompson</name></noRegion></country><country name="Pologne"><noRegion><name sortKey="Flisiak, Robert" sort="Flisiak, Robert" uniqKey="Flisiak R" first="Robert" last="Flisiak">Robert Flisiak</name></noRegion></country><country name="Turquie"><noRegion><name sortKey="Akarca, Ulus Salih" sort="Akarca, Ulus Salih" uniqKey="Akarca U" first="Ulus Salih" last="Akarca">Ulus Salih Akarca</name></noRegion></country><country name="Bulgarie"><region name="Sofia-ville (oblast)"><name sortKey="Tchernev, Konstantin G" sort="Tchernev, Konstantin G" uniqKey="Tchernev K" first="Konstantin G" last="Tchernev">Konstantin G. Tchernev</name></region></country><country name="France"><noRegion><name sortKey="Marcellin, Patrick" sort="Marcellin, Patrick" uniqKey="Marcellin P" first="Patrick" last="Marcellin">Patrick Marcellin</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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